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In chemotherapy-naïve patients with MM, ramucirumab has been used alone or in combination with dacarbazine, yielding median progression-free survival rates of 2.6 months for combination therapy and 1.7 months for ramucirumab alone with an acceptable safety profile (NCT00533702) 206

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10.1002/acn3.186 [DOI] [PMC free article] [PubMed] [Google Scholar] Kitamura K., Fujiyoshi K., Yamane J., Toyota F., Hikishima K., Nomura T., et al